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  Indian J Med Microbiol
 

Figure 4: Pro- and Anti-apoptotic Protein Expression. Alterations in levels of (a) caspase-3, (b) cleaved caspase-3, (c) Bax and (d) Bcl-2 protein as well as in the (e) Bcl-2/Bax ratio after ischemia were demonstrated. Compared to control group, all the ischemia groups saw an increase in the expression of pro-apoptotic proteins (*P < 0.05, a-c), reduced levels anti-apoptotic proteins (*P < 0.05, d), and increases in the Bcl-2/Bax ratio (***P < 0.001, e) at 24 h. Both the 2-h and 4- ischemia groups had slightly increased caspase-3 expression (a) and reduced Bax expression (c) compared to the permanent ischemia group. The 2-h ischemia group had slightly reduced cleaved caspase-3 level, while an increase was observed in 4-h ischemia group compared to the permanent ischemia group (b). Both the 2-hour and 4-h ischemia groups saw the same levels of Bcl-2 (d) and Bcl-2/Bax ratio (e) compared to the permanent ischemia group

Figure 4: Pro- and Anti-apoptotic Protein Expression. Alterations in levels of (a) caspase-3, (b) cleaved caspase-3, (c) Bax and (d) Bcl-2 protein as well as in the (e) Bcl-2/Bax ratio after ischemia were demonstrated. Compared to control group, all the ischemia groups saw an increase in the expression of pro-apoptotic proteins (*<i>P</i> < 0.05, a-c), reduced levels anti-apoptotic proteins (*<i>P</i> < 0.05, d), and increases in the Bcl-2/Bax ratio (***<i>P</i> < 0.001, e) at 24 h. Both the 2-h and 4- ischemia groups had slightly increased caspase-3 expression (a) and reduced Bax expression (c) compared to the permanent ischemia group. The 2-h ischemia group had slightly reduced cleaved caspase-3 level, while an increase was observed in 4-h ischemia group compared to the permanent ischemia group (b). Both the 2-hour and 4-h ischemia groups saw the same levels of Bcl-2 (d) and Bcl-2/Bax ratio (e) compared to the permanent ischemia group