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  Citation statistics : Table of Contents
   2018| October-December  | Volume 3 | Issue 4  
    Online since January 25, 2019

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Climate change and occupational health of outdoor workers: An urgent call to action for European policymakers
Francesco Chirico, Giuseppe Taino
October-December 2018, 3(4):77-79
  3 3,519 494
Acute necrotizing encephalopathy in children: A case report and literature review
Ping Yuan, Min Zhong
October-December 2018, 3(4):83-87
Acute necrotizing encephalopathy (ANE) is a rare clinical-imaging syndrome with unknown etiology, characterized by acute fulminant severe encephalopathy and brain damage with multifocal symmetry. ANE has no specific clinical symptoms and signs, similar to common encephalitis or encephalopathy symptoms. The characteristic brain imaging examination is diagnostically significant. To date, no specific treatment for ANE is available and the prognosis is poor. Here, we reported a typical case of ANE in a child, and where a good outcome was achieved through combined therapy with immunoglobulin and glucocorticoids.
  - 3,810 314
Implementing measures to minimize the measles-associated deaths and accomplish global elimination
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava
October-December 2018, 3(4):88-89
  - 2,984 259
The primary unfolded protein response transducer endoplasmic reticulum-to-nucleus signaling 1 is downregulated in livers of human nonalcoholic steatohepatitis patients
El Hussain Shamsa, Kezhong Zhang
October-December 2018, 3(4):80-82
Background: The Unfolded Protein Response (UPR) is an elegant signaling pathway from the Endoplasmic Reticulum (ER) to protect cells from stress caused by accumulation of unfolded or misfolded proteins in the ER lumen. ER-to-Nucleus Signaling 1 (IRE1, also called ERN1), an ER-localized protein kinase and endoribonuclease (RNase), is the most conserved transducer of the UPR signaling pathway. In this study, we investigated expression levels of IRE1 in the livers of human non-alcoholic steatohepatitis (NASH) patients. Methods: We analyzed the expression profiles of the primary UPR transducer IRE1 in the livers of human NASH patients based on the microarray gene expression datasets obtained from public domain. Results: Our analyses indicated that expression levels of IRE1 were decreased in the livers of human obese patients with NASH, compared to those of obese patients without NASH. Conclusions: Our analysis result is consistent with the role of IRE1-mediated UPR in preserving cellular homeostasis and functions and in protecting organisms from injuries. This study provides important information in regard to the activation and functional involvement of the UPR signaling pathway in human NASH.
  - 3,343 421