Advanced Search
Users Online: 797
Home
About us
Editorial board
Ahead of print
Current issue
Search
Archives
Submit article
Instructions
Contacts
Reader Login
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Citation statistics : Table of Contents
2018| October-December | Volume 3 | Issue 4
Online since
January 25, 2019
Archives
Previous Issue
Next Issue
Most popular articles
Most cited articles
Show all abstracts
Show selected abstracts
Export selected to
Cited
Viewed
PDF
COMMENTARY
Climate change and occupational health of outdoor workers: An urgent call to action for European policymakers
Francesco Chirico, Giuseppe Taino
October-December 2018, 3(4):77-79
DOI
:10.4103/ed.ed_15_18
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[CITATIONS]
3
3,501
494
CASE REPORT
Acute necrotizing encephalopathy in children: A case report and literature review
Ping Yuan, Min Zhong
October-December 2018, 3(4):83-87
DOI
:10.4103/ed.ed_20_18
Acute necrotizing encephalopathy (ANE) is a rare clinical-imaging syndrome with unknown etiology, characterized by acute fulminant severe encephalopathy and brain damage with multifocal symmetry. ANE has no specific clinical symptoms and signs, similar to common encephalitis or encephalopathy symptoms. The characteristic brain imaging examination is diagnostically significant. To date, no specific treatment for ANE is available and the prognosis is poor. Here, we reported a typical case of ANE in a child, and where a good outcome was achieved through combined therapy with immunoglobulin and glucocorticoids.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
-
3,792
312
LETTER TO EDITOR
Implementing measures to minimize the measles-associated deaths and accomplish global elimination
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava
October-December 2018, 3(4):88-89
DOI
:10.4103/ed.ed_21_18
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
-
2,962
258
ORIGINAL ARTICLE
The primary unfolded protein response transducer endoplasmic reticulum-to-nucleus signaling 1 is downregulated in livers of human nonalcoholic steatohepatitis patients
El Hussain Shamsa, Kezhong Zhang
October-December 2018, 3(4):80-82
DOI
:10.4103/ed.ed_1_19
Background:
The Unfolded Protein Response (UPR) is an elegant signaling pathway from the Endoplasmic Reticulum (ER) to protect cells from stress caused by accumulation of unfolded or misfolded proteins in the ER lumen. ER-to-Nucleus Signaling 1 (IRE1, also called ERN1), an ER-localized protein kinase and endoribonuclease (RNase), is the most conserved transducer of the UPR signaling pathway. In this study, we investigated expression levels of IRE1 in the livers of human non-alcoholic steatohepatitis (NASH) patients.
Methods:
We analyzed the expression profiles of the primary UPR transducer IRE1 in the livers of human NASH patients based on the microarray gene expression datasets obtained from public domain.
Results:
Our analyses indicated that expression levels of IRE1 were decreased in the livers of human obese patients with NASH, compared to those of obese patients without NASH.
Conclusions:
Our analysis result is consistent with the role of IRE1-mediated UPR in preserving cellular homeostasis and functions and in protecting organisms from injuries. This study provides important information in regard to the activation and functional involvement of the UPR signaling pathway in human NASH.
[ABSTRACT]
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
-
3,321
419
Sitemap
|
What's New
|
Feedback
|
Disclaimer
|
Privacy Notice
© Environmental Disease | Published by Wolters Kluwer -
Medknow
Online since 30
th
December, 2015
![[JOURNAL_FULL_NAME]](images/logo.gif){kind=logo}
