A critical evaluation of anthropological, biochemical, and geo-climatic factors related to chronic kidney disease with unknown etiology in Sri Lanka :Santhushya Hewapathirange, Ayesha Madagedara, Rohana Chandrajith, Nishantha Nannayakkara, Environmental Disease

ORIGINAL ARTICLE
Year : 2023 | Volume : 8 | Issue : 1 | Page : 13--19

A critical evaluation of anthropological, biochemical, and geo-climatic factors related to chronic kidney disease with unknown etiology in Sri Lanka

Santhushya Hewapathirange¹, Ayesha Madagedara², Rohana Chandrajith³, Nishantha Nannayakkara¹
¹ Center for Research, National Hospital, Kandy, Sri Lanka
² Center for Research, National Hospital, Kandy; Department of Fundamentals of Nursing, Faculty of Nursing, University of Colombo, Colombo, Sri Lanka
³ Department of Geology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka

Correspondence Address:
Nishantha Nannayakkara
Center for Research, National Hospital, Kandy
Sri Lanka

Background: Chronic kidney disease of unknown etiology (CKDu) is a critical health issue among farming communities of the dry zone in Sri Lanka. Aims and Objectives: This study was conducted to identify the possible anthropological, biochemical, and geo-environmental characteristics of CKDu, comparing an affected and nonaffected community. Materials and Methods: Serum creatinine (SC) levels were measured and estimated glomerular filtration rate values were calculated in both communities based on a stratified sampling method. Anthropological data, such as population structure, farming behavior, and poverty statistics, were obtained from the respective government officials. Geo-climatic data including elevation, monthly average temperature, rainfall, humidity, ultraviolet intensity, and sunshine hours were obtained for study areas. Results: The most striking difference between the two communities is significantly high SC in male individuals between the age categories of 40–60 in the CKDu endemic area in comparison to nonendemic participants in the same age category from the nonendemic area. Conclusion: Significant differences were observed in migration, drinking water sources, and hot humid environment between the two studied regions.

How to cite this article:
Hewapathirange S, Madagedara A, Chandrajith R, Nannayakkara N. A critical evaluation of anthropological, biochemical, and geo-climatic factors related to chronic kidney disease with unknown etiology in Sri Lanka.Environ Dis 2023;8:13-19

How to cite this URL:
Hewapathirange S, Madagedara A, Chandrajith R, Nannayakkara N. A critical evaluation of anthropological, biochemical, and geo-climatic factors related to chronic kidney disease with unknown etiology in Sri Lanka. Environ Dis [serial online] 2023 [cited 2023 Jun 4 ];8:13-19
Available from: http://www.environmentmed.org/article.asp?issn=2468-5690;year=2023;volume=8;issue=1;spage=13;epage=19;aulast=Hewapathirange;type=0