Environmental Disease

REVIEW ARTICLE
Year
: 2021  |  Volume : 6  |  Issue : 4  |  Page : 111--115

PM2.5 pollution and endoplasmic reticulum stress response


Eric Heng1, Areeba Maysun1, Kezhong Zhang2 
1 Center for Molecular Medicine and Genetics, Detroit, MI, USA
2 Center for Molecular Medicine and Genetics; Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI, USA

Correspondence Address:
Kezhong Zhang
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 E. Canfield Avenue, Detroit, MI 48201
USA

Air pollution is a sustained problem of public health for the general population in urban areas, especially for those living in areas of intensive traffic or industrial activity. Accumulating evidence has confirmed a significant association between exposure to fine ambient particulate matter with aerodynamic diameters <2.5 μm (PM2.5) and the increase of morbidity and mortality associated with cardiovascular and metabolic diseases. It has been identified that inflammation and intracellular stress responses play important roles in PM2.5-caused pathogenesis. Unfolded protein response (UPR) is an intracellular stress signaling from the endoplasmic reticulum (ER) to help cell recovery from the stress caused by the accumulation of unfolded or misfolded proteins. Exposure to high levels of environmentally relevant PM2.5 may directly or indirectly interrupt the protein folding process in the ER, causing ER stress. A number of studies suggested that ER stress response, or UPR, interacts with mitochondrial stress and inflammatory responses, under PM2.5 exposure, to modulate functions and survival of specialized cell types that are involved in the development of cardiovascular, metabolic, and neurodegenerative diseases. In this review, we summarize the recent advance in understanding the mechanistic links between PM2.5 and ER stress response.


How to cite this article:
Heng E, Maysun A, Zhang K. PM2.5 pollution and endoplasmic reticulum stress response.Environ Dis 2021;6:111-115


How to cite this URL:
Heng E, Maysun A, Zhang K. PM2.5 pollution and endoplasmic reticulum stress response. Environ Dis [serial online] 2021 [cited 2022 Jul 3 ];6:111-115
Available from: http://www.environmentmed.org/article.asp?issn=2468-5690;year=2021;volume=6;issue=4;spage=111;epage=115;aulast=Heng;type=0