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Year : 2023  |  Volume : 8  |  Issue : 1  |  Page : 13-19

A critical evaluation of anthropological, biochemical, and geo-climatic factors related to chronic kidney disease with unknown etiology in Sri Lanka

1 Center for Research, National Hospital, Kandy, Sri Lanka
2 Center for Research, National Hospital, Kandy; Department of Fundamentals of Nursing, Faculty of Nursing, University of Colombo, Colombo, Sri Lanka
3 Department of Geology, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka

Correspondence Address:
Nishantha Nannayakkara
Center for Research, National Hospital, Kandy
Sri Lanka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ed.ed_27_22

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Background: Chronic kidney disease of unknown etiology (CKDu) is a critical health issue among farming communities of the dry zone in Sri Lanka. Aims and Objectives: This study was conducted to identify the possible anthropological, biochemical, and geo-environmental characteristics of CKDu, comparing an affected and nonaffected community. Materials and Methods: Serum creatinine (SC) levels were measured and estimated glomerular filtration rate values were calculated in both communities based on a stratified sampling method. Anthropological data, such as population structure, farming behavior, and poverty statistics, were obtained from the respective government officials. Geo-climatic data including elevation, monthly average temperature, rainfall, humidity, ultraviolet intensity, and sunshine hours were obtained for study areas. Results: The most striking difference between the two communities is significantly high SC in male individuals between the age categories of 40–60 in the CKDu endemic area in comparison to nonendemic participants in the same age category from the nonendemic area. Conclusion: Significant differences were observed in migration, drinking water sources, and hot humid environment between the two studied regions.

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