• Users Online: 90
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 5  |  Issue : 1  |  Page : 3-8

Effect of monosodium glutamate (MSG) on behavior, body and brain weights of exposed rats


Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria

Correspondence Address:
Uche Stephen Akataobi
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Cross River State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ed.ed_31_19

Rights and Permissions

Purpose: Consumption of monosodium glutamate (MSG) in food, drink, and other consumables has been linked to different observable changes believed to be as a result of MSG's effects on the brain. Furthermore, it is believed that blood–brain barrier plays a role on how these effects are felt in different stages of life. The present study is an attempt to understand the differential effect of MSG by studying body and brain weights as well as physiological changes in the behavior of rats exposed at different stages of life (either as neonate or as adult). Materials and Methods: Pups were administered 4 mg/g MSG on postnatal days 2, 4, 6, 8, and 10, allowed to mature for 26 weeks, and afterward divided into three groups (n = 6) and administered saline, 5 mg/g, and 10 mg/g MSG for 6 weeks. Two other groups, not exposed to MSG at neonatal age (adult), were similarly administered 5 mg/g and 10 mg/g MSG for 6 weeks. During this period, weight gain and behavioral observation was made, and at the end of the 6 weeks, brain weight was measured. Results: A dose-dependent effect of MSG was recorded in both neonatal- and adult-administered rats in all the parameters studied. Conclusion: MSG affects both neonate and adult rats similarly, thus adult exposure may be used in studies involving MSG and other neurotoxic chemicals.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3579    
    Printed86    
    Emailed0    
    PDF Downloaded306    
    Comments [Add]    
    Cited by others 1    

Recommend this journal