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REVIEW ARTICLE
Year : 2016  |  Volume : 1  |  Issue : 2  |  Page : 51-57

A review of nonalcoholic fatty liver disease - genetics and animal models


Department of Medicine, Columbia University, New York, NY 10032, USA

Correspondence Address:
Ze Zheng
Department of Medicine, Columbia University, New York, NY 10032
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2468-5690.185292

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Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple NAFL to nonalcoholic steatohepatitis, to irreversible cirrhosis. NAFLD is the most common chronic liver disease in developed countries and is considered as the hepatic manifestation of cardiovascular disease and metabolic syndrome. In the pathogenesis of NAFLD, hepatic lipid accumulation results from an imbalance between lipid synthesis, storage, oxidation, and/or secretion, and eventually triggers hepatic inflammation and injury. The increasing incidence of NAFLD etiological studies has shown that obesity, hepatitis C, and cryptogenic cirrhosis are associated with NAFLD. Here, we provide a comprehensive NAFLD review that covers the population genetics, genome-wide associated study, epidemiology, pathophysiology of the disease progression, and current existing animal models.


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