• Users Online: 492
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Contacts Login 
Year : 2016  |  Volume : 1  |  Issue : 2  |  Page : 51-57

A review of nonalcoholic fatty liver disease - genetics and animal models

Department of Medicine, Columbia University, New York, NY 10032, USA

Correspondence Address:
Ze Zheng
Department of Medicine, Columbia University, New York, NY 10032
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2468-5690.185292

Rights and Permissions

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple NAFL to nonalcoholic steatohepatitis, to irreversible cirrhosis. NAFLD is the most common chronic liver disease in developed countries and is considered as the hepatic manifestation of cardiovascular disease and metabolic syndrome. In the pathogenesis of NAFLD, hepatic lipid accumulation results from an imbalance between lipid synthesis, storage, oxidation, and/or secretion, and eventually triggers hepatic inflammation and injury. The increasing incidence of NAFLD etiological studies has shown that obesity, hepatitis C, and cryptogenic cirrhosis are associated with NAFLD. Here, we provide a comprehensive NAFLD review that covers the population genetics, genome-wide associated study, epidemiology, pathophysiology of the disease progression, and current existing animal models.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded522    
    Comments [Add]    

Recommend this journal